Publications and Abstracts

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    ?Apoptosis in OC-k3 immortalized cell line treated with different agents? L. Bertolaso, A. Martini, D. Bindini, I. Lanzoni, A. Parmeggiani, C. Vitali, G. Kalinec, F.Kalinec, S. Capitani, M. Previati. Audiolgy 2001 Nov-Dec; 40(6):327-335

    "Gentamicin-induced cytotoxicity involves PKC activation, GSH extrusion and reactive oxygen species production in an immortalized cell line from the organ of Corti" L. Bertolaso, D. Bindini, M. Previati, D. Falgione, I. Lanzoni, A. Parmeggiani, C. Vitali, S. Capitani, A. Martini. Audiology and Neuro-Otology in revisione in data aprile 2002.

  • Hatzopoulos S., Di Stefano M., Albertin A. and Martini A. "Evaluation of Cisplatin Ototoxicity in a Rat Animal Model" Annals of the New York Academy of Sciences Volume 884, 1999, pp 211-225


    The ototoxic effects of cisplatin were evaluated by otoacoustic emissions and evoked auditory responses. A transient otoacoustic emissions protocol indicated no significant ototoxic effects in rats treated intravenously with 7.5 mg/kg/week for 2-weeks. A chronic 6 week treatment (2.5 mg/kg /week) monitored by 2F1-F2 distortion product emissions presented significant S/N ratio alterations in a narrow range of frequencies (5.04- 5.66 kHz). An acute treatment of 15 mg/kg, using slow 30 min intra-peritoneal infusion , presented the highest DP and ABR alterations. The S/N ratio at the 2F1-F2 frequencies 6.34, 7.13, and 7.56 kHz was found significantly decreased and ABR latency measurements from 8K burst stimuli verified these alterations.

  • Martini A, Hatzopoulos S., R. Rubini, Di Stefano M., Albertin A. and E. Govoni
    "An Animal Model Based on the Sprague-Dawley Rat for the Evaluation of Ototoxicity " Annals of the New York Academy of Sciences Volume 884,1999, pp 85-98


    The paper presents various methodological approaches which can be used to detect ototoxic effects caused by the administration of various substances, using as an animal model the Sprague- Dawley rat. Electro-physiological data are also presented to show how the model behaves with potentially ototoxic (Hyaluronic acid) and initially-inert (hydroxy-propyl-methyl-cellulose) substances.


  • Hatzopoulos S., Di Stefano M., Albertin A., Martini A. , " Detection of Cisplatin Ototoxicity in a rat model using otoacoustic emission (OAEs) descriptors . 35th Workshop on Inner Ear Biology, August 29- September 1, 1998, Innsbruck.

  • Hatzopoulos S, Campell, A. Albertin, D. Falgione, D. Ricci, L. Bertolaso, M. Di Stefano, S. Capitani and A. Martini. ?The relationship between ABR thresholds and TEOAE responses in a SD rat animal model treated with cisplatin? . 36th Workshop on Inner Ear Biology, June 26 - 29, 1999, Hensinki.

  • Hatzopoulos, J. Petruccelli, M. Di Stefano, and A. Martini. "The suppressing effect of xylazine-ketamine anesthesia on transient (TEOAE) and distortion product (DPOAE) otoacoustic emissions in a rat animal model." 37th workshop on Inner Ear Biology September 2-5 2000, Upsala Sweden.

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