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I: Papers (in reverse chronological order)
- Hatzopoulos S, Petrucelli J, Morlet T, Martini A.
Otoacoustic Emission Protocols revised. Data from adult subjects (in press, IJA, 2002).
- Hatzopoulos S, Amoroso C, Aimoni C, Lo Monaco A, Govoni M, Martini A.
Hearing loss evaluation of the Sj?gren syndrome by Distortion Product Otoacoustic Emissions (in press, ACTA Scand, 2002).
- Hatzopoulos S., Petruccelli J. , Laurell G., Avan P., Finesso M, and Martini A.
Ototoxic effects of cisplatin in a Sprague Dawley rat animal model as revealed by ABR and transiently evoked otoacoustic emission measurements. (Hearing Research, 2002).
- Hatzopoulos S, Petrucelli J, Laurel G, Finesso M and Martini A
Evaluation of anesthesia effects in a rat animal model using otoacoustic emission protocols (Hearing Research, 2002)
- Zimatore G, Hatzopoulos S, Giuliani A, Martini A, and Colosimo A.
Comparison of Transient Otoacoustic Emission (TEOAE) Responses from Neonatal And Adult Ears. (J.Appl. Physiol, 2002).
- Hatzopoulos S, Petruccelli J, Giarbini N, Rossi M, Vigi V, Chierici R, Guerini P and Martini A
A comparison of distortion product otoacoustic emissions protocols in a Universal Neonatal Hearing Screening (UNHS) program (in press, Journal of Audiological Medicine).
Hatzopoulos S, Di Stefano MD, Campbell KC, Falgione DF, Ricci D, Rosignoli M, Finesso M, Albertin A, Previati M, Capitani S, Martini A
Cisplatin ototoxicity in the Sprague Dawley rat evaluated by distortion product otoacoustic emissions.
Audiology. 2001 Sep-Oct;40(5):253-64.
Hatzopoulos S., Pelosi G, Petruccelli J., Vigi F, Chierici M and Martini A.
Efficient Otoacoustic Emission Protocols employed in a hospital based screening program.Acta Otolaryngol (Stockh).2001 Mar-Apr;39(2):70-9.
Within the context of a hospital based newborn hearing screening program, we have studied the application of two OAE protocols (TEOAE and DPOAE) on a group of 250 well babies. The main goal of this study was to evaluate the performance of DPOAE protocol in a relatively large population sample, using a preset number of five tested frequencies, in comparison to a default TEOAE screening protocol. The data were collected the second day of life and during spontaneous sleep. The TEOAE recordings were acquired with linear protocols using click stimuli of 70-75 dB SPL and were used as indicators of a normal cochlear function. The cubic distortion product DPOAE responses were evoked by an asymmetrical 75-65 dB SPL protocol, with a frequency ratio of 1.22. Five frequencies (referring to F2) were tested at 1.5, 2.0, 3.0, 4.0 and 5.0 kHz. The data from the DPOAE responses show a similar pass rate (similarity =0.98) to the linear TEOAE protocol. The presented data suggest that a DPOAE cochlear evaluation, at 5 pre-selected frequencies, has a clinical potential.
S. Hatzopoulos, M . Tsakanikos, A. Grzanka, J. Ratynska, and A. Martini
A comparison of neonatal TEOAE responses recorded with linear and
QuickScreen protocols.Audiology, 2000 Mar-Apr;39(2):70-9.
Linear and QuickScreen (nonlinear) TEOAE protocols were
compared in terms of standardized clinical parameters in
order to define the protocol producing recordings with the
highest signal quality . The TEOAE data were acquired with
the ILO-92 and ILO-292 apparatus from neonates (520 ears)
in 3 different screening sites. The linear recordings were
evoked by clicks with an intensity of 69 and 75 dB p.e. SPL.
All TEOAE responses were post-windowed by a 3.5 - 12.5 ms
window which was chosen by time frequency analysis as the
segment representing 97.35 % (linear) and 95.6 % (quick)
of the total cumulative spectral energy. Evidence from
hearing loss cases and the high similarity between the
profile contours of the QuickScreen and the linear normal
recordings has strongly suggested that a linear response
evoked by a 75 dB pe. SPL stimulus and post -processed
by a 3.5- 12.5 window is free of stimulus artifacts.
The data comparisons were conducted by paired t-tests
across 8 ILO variables. The results indicated that:
(i) the 69 dB linear protocol produces responses whose
signal characteristics are very similar to those evoked
by a QuickScreen protocol. The latter though generates
better signal to noise ratios at 3.0 kHz ; (ii) the 75 dB
linear protocol produces higher S/N ratios at 2.0, 3.0
and 4.0 kHz, higher wave reproducibility and lower
TEOAE noise values than the QuickScreen protocol,
therefore it can be a better clinical choice for a
Ratynska J., Grzanka A., Mueller-Malesinska M.,
Skarzynski H and , Hatzopoulos S.
Correlation between risk factors for hearing impairment and TEOAE screening
test outcome in neonates at risk for hearing loss. Scandinavian
Establishing the correlation between the risk factors for
hearing loss may allow the modification of the criteria used
in the questionnaires applied in high risk neonatal hearing
screening, as a means to optimize screening sensitivity
and specificity. The aim of this study was to find the
correlation between the simultaneous presence of specific
risk factors for hearing impairment and the correlation
between risk factors and the descriptors of transiently
evoked otoacoustic emission (TEOAE) recordings.
Hatzopoulos S. , Cheng J. ,Grzanka A. and Martini A.
"Time-frequency analyses of TEOAE recordings from normal and SNHL cases"
This study evaluated the characteristics of TEOAE time-frequency (TF)
representations from normal and hearing impaired ears. Linear and
nonlinear TEOAE recordings from normal hearing subjects (40) and
nonlinear recordings from SNHL cases (40) were analyzed by the
short-time-Fourier-transform spectrogram, the Gabor spectrogram
and the adaptive spectrogram. The TF representations of the TEOAE
recordings indicated a considerable dispersion of energy across
various frequencies and TEOAE time-segments > 4.0 ms. The linear
and nonlinear recordings from the normal subjects presented
common frequency peaks. The TF representations from the SNHL
cases indicated that the significantly reduced energy in the mid
to high TEOAE frequencies did not correlated well with the
threshold elevation. As in the recordings from the normal cases
a high percentage of the TEOAE cumulative energy was observed
within a shorter TEOAE segment (4 - 14 ms) .
Hatzopoulos S. , Martini M. , Cheng J., Grzanka A. and Morlet T.
"On the optimization of the TEOAE recording protocols. A linear protocol derived from parameters of a time-frequency analysis . Data from neonatal subjects"
inear and nonlinear TEOAE protocols were compared in terms of
nine parameters in order to define the protocol producing
recordings with the highest signal quality (lower noise and
higher signal-to-noise ratio). The pilot project acquired
data with the ILO-92 apparatus from 220 neonates (397 ears)
at the second / third day of birth in 3 European laboratories.
A time-frequency representation of the recordings showed a
considerable frequency dispersion in TEOAE latencies > 5.0 ms.
The data, analyzed with a Wilcoxon test, indicated that a
linear TEOAE protocol: (1) generates recordings of a lower
noise and a higher signal-to-noise (S/N) ratio in the 2.0,
3.0, 4.0 kHz TEOAE bands; (2) the increase of the S/N ratio
can result in a decrement of the required number of TEOAE
sweeps; (3) the higher values of S/N can be used in the
estimation of more robust pass-fail criteria minimizing
the percentage of false positives and negatives.
Hatzopoulos S., Martini A., Stephens SG
TEOAE-based estimation of the auditory threshold in the mid-octave frequencies.
Br J Audiol. 1999 Dec;33(6):415-22.
Hatzopoulos S., Petruccelli J., Pelosi G., and Martini A.
A TEOAE screening protocol based on linear click stimuli: performance and scoring criteria.
Acta Otolaryngol (Stockh). 1999 Mar;119(2):135-9.
Hatzopoulos S., Di Stefano M., Albertin A. and Martini A.
"Evaluation of Cisplatin Ototoxicity in a Rat Animal Model" Annals of the
New York Academy of Sciences (1999)
The ototoxic effects of cisplatin were evaluated by otoacoustic emissions and
evoked auditory responses. A transient otoacoustic emissions protocol
indicated no significant ototoxic effects in rats treated intravenously
with 7.5 mg/kg/week for 2-weeks. A chronic 6 week treatment (2.5 mg/kg /week)
monitored by 2F1-F2 distortion product emissions presented significant
S/N ratio alterations in a narrow range of frequencies (5.04- 5.66 kHz).
An acute treatment of 15 mg/kg, using slow 30 min intra-peritoneal
infusion , presented the highest DP and ABR alterations. The S/N ratio
at the 2F1-F2 frequencies 6.34, 7.13, and 7.56 kHz was found significantly
decreased and ABR latency measurements from 8K burst stimuli verified these
Hatzopoulos S.,Prosser S., Mazzoli M., Rosignoli M.,
Clinical applicability of transient evoked otoacoustic emissions: identification and classification of hearing loss.
Audiol Neurootol. 1998 Nov-Dec;3(6):402-18.
Hatzopoulos S., Mazzoli M., Martini A.
Identification of hearing loss using TEOAE descriptors: theoretical foundations and preliminary results.
Audiology. 1995 Sep-Oct;34(5):248-59.
II: Papers in Italian
Pelosi G., Hatzopoulos S., Vigi F., Chiarici M., and Martini A.
Evaluation of a linear TEOAE protocol in hearing screening of neonates: feasibility study.
Acta Otorhinolaryngol Ital. 1998 Aug;18(4):213-7.
Pelosi G., Hatzopoulos S., Vigi F., Chiarici M., and Martini A.
Valutazione di un protocollo DPOAE nello screening audiologico neonatale: studio di fattibilit?
Acta Otorhinolaryngol Ital. 2000 Aug;18(4):213-7.
1. Hatzopoulos S., Martini A. " On the Clinical efficiency of the nonlinear TEOAE recording protocols", 3rd European Conference on Audiology,Praga, Czech Republic, 18-21 June 1997.
2. Hatzopoulos S., Martini A. " Value of OAEs for screening of hearing loss" International Conference of Paediatric ORL and Otology Update, 28-31 January 1998, Bangkok, Thailand.
3. Hatzopoulos S., Pelosi G., Rossi M., Macalli S. and Martini A "
An optimized neonatal screening protocol based on linear stimulus
sequences. Collegium ORLAS meeting, Copenhagen 22-26 August, 1998.
4. Hatzopoulos S., Di Stefano M., Albertin A., Martini A. ,
" Detection of Cisplatin Ototoxicity in a rat model using otoacoustic emission (OAEs) descriptors . 35th Workshop on Inner Ear Biology, August 29- September 1, 1998, Innsbruck.
- 5. Hatzopoulos S. And Grzanka A.
"A screening protocol based on linear click stimuli: Performance and scoring criteria". In International Workshop on New Objective Tests in Clinical Audiology and Neuro-Otology, Warsaw, Poland, 24-26 September 1998.
- 6. Grzanka A, and Hatzopoulos S.
"Review of time-frequency distributions in applications to Otoacoustic Emissions". In International Workshop on New Objective Tests in Clinical Audiology and Neuro-Otology, Warsaw, Poland, 24-26 September 1998.
- 7. Hatzopoulos S., Petruccelli J., Prosser S., Pelosi G., and Martini A.
?A neonatal screening protocol based on distortion product otoacoustic emissions (DPOAEs) : Performance and scoring criteria?. 16th IERASG Biennial Symposium, May 30- June 3, 1999, Troms?, Norway.
- 8. Grzanka A, Hatzopoulos S., Ratynska J
?TEOAE interpretation on the regionally smoothed Wigner-Ville distribution?. 16th IERASG Biennial Symposium, May 30- June 3, 1999, Troms?, Norway.
- 9. Hatzopoulos S, Campell, A. Albertin, D. Falgione, D. Ricci, L. Bertolaso, M. Di Stefano, S. Capitani and A. Martini.
?The relationship between ABR thresholds and TEOAE responses in a SD rat animal model treated with cisplatin? . 36th Workshop on Inner Ear Biology, June 26 - 29, 1999, Hensinki.
- 10. Hatzopoulos S, Kibbe K, Petrucelli J, Pelosi G, Martini A. "A feasibility study of a neonatal screening protocol based on distortion product otoacoustic emissions (DPOAEs)", American Auditory Society meeting, April 7-9 , 2000, Phoenix.
- 11. Martini A, Hatzopoulos S, Pelosi G, Petruccelli J, Vigi F, Chierici M. An overview of efficient Otoacoustic Emission protocols employed in a Hospital-based neonatal screening program . Collegium ORLAS meeting, August 20-24, 2000 Washington DC.
- 12. Hatzopoulos S., Pelosi G., Prosser S., Guerrini F., Vigi G.,, and Martini A. "Efficient otoacoustic emission protocols applied on low birth-weight NICU residents" International Congress of Audiology, 27-31 August 2000, Hague. Holland.
- 13. Hatzopoulos, J. Petruccelli, M. Di Stefano, and A. Martini. The suppressing effect of xylazine-ketamine anesthesia on transient (TEOAE) and distortion product (DPOAE) otoacoustic emissions in a rat animal model. 37th workshop on Inner Ear Biology September 2-5 2000, Upsala Sweden.
- 14. Martini A, Hatzopoulos S, Petruccelli J, Pelosi G, Kibbe K, Guerrini M, Vigi V. Transient and Distortion Product Otoacoustic Emission Protocols Applied on Low-Birth NICU residents, NHS conference on Neonatal Screening, Milano October 12-14, 2000.
- 15. Martini A, Hatzopoulos S, Pelosi G, Petruccelli J, Vigi F, Chierici M.
An overview of efficient Otoacoustic Emission protocols employed in a Hospital-based neonatal screening program . Collegium ORLAS meeting, August 20-24, 2000 Washington DC.
- 16. Hatzopoulos S., Pelosi G., Prosser S., Guerrini F., Vigi G.,, and Martini A.
"Efficient otoacoustic emission protocols applied on low birth-weight NICU residents" International Congress of Audiology, 27-31 August 2000, Hague. Holland.
- 17. Hatzopoulos, J. Petruccelli, M. Di Stefano, and A. Martini
The suppressing effect of xylazine-ketamine anesthesia on transient (TEOAE) and distortion product (DPOAE) otoacoustic emissions in a rat animal model. 37th workshop on Inner Ear Biology September 2-5 2000, Upsala Sweden.
- 18. Martini A, Hatzopoulos S, Petruccelli J, Pelosi G, Kibbe K, Guerrini M, Vigi V.
Transient and Distortion Product Otoacoustic Emission Protocols Applied on Low-Birth NICU residents, NHS conference on Neonatal Screening, Milano October 12-14, 2000.
- 19. Hatzopoulos S., Petruccelli. G, Martini A. Lewis, D.R., Russo, ICP and Almeida, K.
Neonatal screening with DPOEs protocols in Italy and Brazil. American Academy of Audiology, Annual meeting, Chicago March 17-19, 2001.
- 20. Hatzopoulos S., Petruccelli J.,Kibbe K., and Martini A.
Otoacoustic Emission Responses from Low-Birth NICU residents, American Society of Audiology, Annual meeting, Scottsdale Arizona, March 15-17, 2001.
- 21. Grzanka A, Konopka W, Hatzopoulos S, Zalewski P.
TEOAE high resolution time-frequency components and their long term stability, IERASG meeting June 21-27 Vancouver Canada, 2001.
- 22. Hatzopoulos S. Petruccelli J., and Martini A.
Evaluation of anesthesia effects in a rat animal model using hig and medium stimulus intensity otoacoustic emission protocols. Inner Ear Biology meeting, Rome, September 1-4, 2001.
- 23. S. Hatzopoulos, T. Morlet, J. Petruccelli , P. Guerrini, Rigon F, Rossi M and A. Martini
Factors affecting the maturation of OAE responses of Low-Birth NICU residents, NHS meeting Como, May 31, 2002.
- 24. Martini A, Previati M, Bertolaso L, Lanzoni I, Bindini D, Hatzopoulos S,
Singnal transduction due to ototoxic drugs in OCK3. Pharmacological protection of the Inner Ear, Rome May 3-4, 2002.