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I: Papers (in reverse chronological order)



  • Hatzopoulos S, Petrucelli J, Morlet T, Martini A. Otoacoustic Emission Protocols revised. Data from adult subjects (in press, IJA, 2002).

  • Hatzopoulos S, Amoroso C, Aimoni C, Lo Monaco A, Govoni M, Martini A. Hearing loss evaluation of the Sj?gren syndrome by Distortion Product Otoacoustic Emissions (in press, ACTA Scand, 2002).      Download Article

  • Hatzopoulos S., Petruccelli J. , Laurell G., Avan P., Finesso M, and Martini A. Ototoxic effects of cisplatin in a Sprague Dawley rat animal model as revealed by ABR and transiently evoked otoacoustic emission measurements. (Hearing Research, 2002).      Download Article

  • Hatzopoulos S, Petrucelli J, Laurel G, Finesso M and Martini A Evaluation of anesthesia effects in a rat animal model using otoacoustic emission protocols (Hearing Research, 2002)      Download Article

  • Zimatore G, Hatzopoulos S, Giuliani A, Martini A, and Colosimo A. Comparison of Transient Otoacoustic Emission (TEOAE) Responses from Neonatal And Adult Ears. (J.Appl. Physiol, 2002).      Download Article

  • Hatzopoulos S, Petruccelli J, Giarbini N, Rossi M, Vigi V, Chierici R, Guerini P and Martini A A comparison of distortion product otoacoustic emissions protocols in a Universal Neonatal Hearing Screening (UNHS) program (in press, Journal of Audiological Medicine).

  • Hatzopoulos S, Di Stefano MD, Campbell KC, Falgione DF, Ricci D, Rosignoli M, Finesso M, Albertin A, Previati M, Capitani S, Martini A Cisplatin ototoxicity in the Sprague Dawley rat evaluated by distortion product otoacoustic emissions. Audiology. 2001 Sep-Oct;40(5):253-64.       Download Article

  • Hatzopoulos S., Pelosi G, Petruccelli J., Vigi F, Chierici M and Martini A. Efficient Otoacoustic Emission Protocols employed in a hospital based screening program.Acta Otolaryngol (Stockh).2001 Mar-Apr;39(2):70-9.

    ABSTRACT
    Within the context of a hospital based newborn hearing screening program, we have studied the application of two OAE protocols (TEOAE and DPOAE) on a group of 250 well babies. The main goal of this study was to evaluate the performance of DPOAE protocol in a relatively large population sample, using a preset number of five tested frequencies, in comparison to a default TEOAE screening protocol. The data were collected the second day of life and during spontaneous sleep. The TEOAE recordings were acquired with linear protocols using click stimuli of 70-75 dB SPL and were used as indicators of a normal cochlear function. The cubic distortion product DPOAE responses were evoked by an asymmetrical 75-65 dB SPL protocol, with a frequency ratio of 1.22. Five frequencies (referring to F2) were tested at 1.5, 2.0, 3.0, 4.0 and 5.0 kHz. The data from the DPOAE responses show a similar pass rate (similarity =0.98) to the linear TEOAE protocol. The presented data suggest that a DPOAE cochlear evaluation, at 5 pre-selected frequencies, has a clinical potential.


  • S. Hatzopoulos, M . Tsakanikos, A. Grzanka, J. Ratynska, and A. Martini A comparison of neonatal TEOAE responses recorded with linear and QuickScreen protocols.Audiology, 2000 Mar-Apr;39(2):70-9.

    ABSTRACT
    Linear and QuickScreen (nonlinear) TEOAE protocols were compared in terms of standardized clinical parameters in order to define the protocol producing recordings with the highest signal quality . The TEOAE data were acquired with the ILO-92 and ILO-292 apparatus from neonates (520 ears) in 3 different screening sites. The linear recordings were evoked by clicks with an intensity of 69 and 75 dB p.e. SPL. All TEOAE responses were post-windowed by a 3.5 - 12.5 ms window which was chosen by time frequency analysis as the segment representing 97.35 % (linear) and 95.6 % (quick) of the total cumulative spectral energy. Evidence from hearing loss cases and the high similarity between the profile contours of the QuickScreen and the linear normal recordings has strongly suggested that a linear response evoked by a 75 dB pe. SPL stimulus and post -processed by a 3.5- 12.5 window is free of stimulus artifacts. The data comparisons were conducted by paired t-tests across 8 ILO variables. The results indicated that: (i) the 69 dB linear protocol produces responses whose signal characteristics are very similar to those evoked by a QuickScreen protocol. The latter though generates better signal to noise ratios at 3.0 kHz ; (ii) the 75 dB linear protocol produces higher S/N ratios at 2.0, 3.0 and 4.0 kHz, higher wave reproducibility and lower TEOAE noise values than the QuickScreen protocol, therefore it can be a better clinical choice for a screening program.


  • Ratynska J., Grzanka A., Mueller-Malesinska M., Skarzynski H and , Hatzopoulos S. Correlation between risk factors for hearing impairment and TEOAE screening test outcome in neonates at risk for hearing loss. Scandinavian Audiology, Mar-Apr;39(2):70-9

    ABSTRACT
    Establishing the correlation between the risk factors for hearing loss may allow the modification of the criteria used in the questionnaires applied in high risk neonatal hearing screening, as a means to optimize screening sensitivity and specificity. The aim of this study was to find the correlation between the simultaneous presence of specific risk factors for hearing impairment and the correlation between risk factors and the descriptors of transiently evoked otoacoustic emission (TEOAE) recordings.



  • Hatzopoulos S. , Cheng J. ,Grzanka A. and Martini A. "Time-frequency analyses of TEOAE recordings from normal and SNHL cases" Audiology.2000 Jan-Feb;39(1):1-12.

    ABSTRACT
    This study evaluated the characteristics of TEOAE time-frequency (TF) representations from normal and hearing impaired ears. Linear and nonlinear TEOAE recordings from normal hearing subjects (40) and nonlinear recordings from SNHL cases (40) were analyzed by the short-time-Fourier-transform spectrogram, the Gabor spectrogram and the adaptive spectrogram. The TF representations of the TEOAE recordings indicated a considerable dispersion of energy across various frequencies and TEOAE time-segments > 4.0 ms. The linear and nonlinear recordings from the normal subjects presented common frequency peaks. The TF representations from the SNHL cases indicated that the significantly reduced energy in the mid to high TEOAE frequencies did not correlated well with the threshold elevation. As in the recordings from the normal cases a high percentage of the TEOAE cumulative energy was observed within a shorter TEOAE segment (4 - 14 ms) .


  • Hatzopoulos S. , Martini M. , Cheng J., Grzanka A. and Morlet T.
    "On the optimization of the TEOAE recording protocols. A linear protocol derived from parameters of a time-frequency analysis . Data from neonatal subjects" Scandinavian Audiology:2000;29(1):21-7

    ABSTRACT L
    inear and nonlinear TEOAE protocols were compared in terms of nine parameters in order to define the protocol producing recordings with the highest signal quality (lower noise and higher signal-to-noise ratio). The pilot project acquired data with the ILO-92 apparatus from 220 neonates (397 ears) at the second / third day of birth in 3 European laboratories. A time-frequency representation of the recordings showed a considerable frequency dispersion in TEOAE latencies > 5.0 ms. The data, analyzed with a Wilcoxon test, indicated that a linear TEOAE protocol: (1) generates recordings of a lower noise and a higher signal-to-noise (S/N) ratio in the 2.0, 3.0, 4.0 kHz TEOAE bands; (2) the increase of the S/N ratio can result in a decrement of the required number of TEOAE sweeps; (3) the higher values of S/N can be used in the estimation of more robust pass-fail criteria minimizing the percentage of false positives and negatives.


  • Hatzopoulos S., Martini A., Stephens SG
    TEOAE-based estimation of the auditory threshold in the mid-octave frequencies.
    Br J Audiol. 1999 Dec;33(6):415-22.

  • Hatzopoulos S., Petruccelli J., Pelosi G., and Martini A.
    A TEOAE screening protocol based on linear click stimuli: performance and scoring criteria.
    Acta Otolaryngol (Stockh). 1999 Mar;119(2):135-9.


  • Hatzopoulos S., Di Stefano M., Albertin A. and Martini A. "Evaluation of Cisplatin Ototoxicity in a Rat Animal Model" Annals of the New York Academy of Sciences (1999)

    ABSTRACT
    The ototoxic effects of cisplatin were evaluated by otoacoustic emissions and evoked auditory responses. A transient otoacoustic emissions protocol indicated no significant ototoxic effects in rats treated intravenously with 7.5 mg/kg/week for 2-weeks. A chronic 6 week treatment (2.5 mg/kg /week) monitored by 2F1-F2 distortion product emissions presented significant S/N ratio alterations in a narrow range of frequencies (5.04- 5.66 kHz). An acute treatment of 15 mg/kg, using slow 30 min intra-peritoneal infusion , presented the highest DP and ABR alterations. The S/N ratio at the 2F1-F2 frequencies 6.34, 7.13, and 7.56 kHz was found significantly decreased and ABR latency measurements from 8K burst stimuli verified these alterations.


  • Hatzopoulos S.,Prosser S., Mazzoli M., Rosignoli M., Martini A. Clinical applicability of transient evoked otoacoustic emissions: identification and classification of hearing loss.
    Audiol Neurootol. 1998 Nov-Dec;3(6):402-18.
  • Hatzopoulos S., Mazzoli M., Martini A. Identification of hearing loss using TEOAE descriptors: theoretical foundations and preliminary results.
    Audiology. 1995 Sep-Oct;34(5):248-59.



II: Papers in Italian



  • Pelosi G., Hatzopoulos S., Vigi F., Chiarici M., and Martini A.
    Evaluation of a linear TEOAE protocol in hearing screening of neonates: feasibility study.
    Acta Otorhinolaryngol Ital. 1998 Aug;18(4):213-7.

  • Pelosi G., Hatzopoulos S., Vigi F., Chiarici M., and Martini A.
    Valutazione di un protocollo DPOAE nello screening audiologico neonatale: studio di fattibilit?
    Acta Otorhinolaryngol Ital. 2000 Aug;18(4):213-7.




III: Abstracts



  • 1. Hatzopoulos S., Martini A. " On the Clinical efficiency of the nonlinear TEOAE recording protocols", 3rd European Conference on Audiology,Praga, Czech Republic, 18-21 June 1997.

  • 2. Hatzopoulos S., Martini A. " Value of OAEs for screening of hearing loss" International Conference of Paediatric ORL and Otology Update, 28-31 January 1998, Bangkok, Thailand.

  • 3. Hatzopoulos S., Pelosi G., Rossi M., Macalli S. and Martini A " An optimized neonatal screening protocol based on linear stimulus sequences. Collegium ORLAS meeting, Copenhagen 22-26 August, 1998.

  • 4. Hatzopoulos S., Di Stefano M., Albertin A., Martini A. , " Detection of Cisplatin Ototoxicity in a rat model using otoacoustic emission (OAEs) descriptors . 35th Workshop on Inner Ear Biology, August 29- September 1, 1998, Innsbruck.

  • 5. Hatzopoulos S. And Grzanka A. "A screening protocol based on linear click stimuli: Performance and scoring criteria". In International Workshop on New Objective Tests in Clinical Audiology and Neuro-Otology, Warsaw, Poland, 24-26 September 1998.

  • 6. Grzanka A, and Hatzopoulos S. "Review of time-frequency distributions in applications to Otoacoustic Emissions". In International Workshop on New Objective Tests in Clinical Audiology and Neuro-Otology, Warsaw, Poland, 24-26 September 1998.

  • 7. Hatzopoulos S., Petruccelli J., Prosser S., Pelosi G., and Martini A. ?A neonatal screening protocol based on distortion product otoacoustic emissions (DPOAEs) : Performance and scoring criteria?. 16th IERASG Biennial Symposium, May 30- June 3, 1999, Troms?, Norway.

  • 8. Grzanka A, Hatzopoulos S., Ratynska J ?TEOAE interpretation on the regionally smoothed Wigner-Ville distribution?. 16th IERASG Biennial Symposium, May 30- June 3, 1999, Troms?, Norway.

  • 9. Hatzopoulos S, Campell, A. Albertin, D. Falgione, D. Ricci, L. Bertolaso, M. Di Stefano, S. Capitani and A. Martini. ?The relationship between ABR thresholds and TEOAE responses in a SD rat animal model treated with cisplatin? . 36th Workshop on Inner Ear Biology, June 26 - 29, 1999, Hensinki.

  • 10. Hatzopoulos S, Kibbe K, Petrucelli J, Pelosi G, Martini A. "A feasibility study of a neonatal screening protocol based on distortion product otoacoustic emissions (DPOAEs)", American Auditory Society meeting, April 7-9 , 2000, Phoenix.

  • 11. Martini A, Hatzopoulos S, Pelosi G, Petruccelli J, Vigi F, Chierici M. An overview of efficient Otoacoustic Emission protocols employed in a Hospital-based neonatal screening program . Collegium ORLAS meeting, August 20-24, 2000 Washington DC.

  • 12. Hatzopoulos S., Pelosi G., Prosser S., Guerrini F., Vigi G.,, and Martini A. "Efficient otoacoustic emission protocols applied on low birth-weight NICU residents" International Congress of Audiology, 27-31 August 2000, Hague. Holland.

  • 13. Hatzopoulos, J. Petruccelli, M. Di Stefano, and A. Martini. The suppressing effect of xylazine-ketamine anesthesia on transient (TEOAE) and distortion product (DPOAE) otoacoustic emissions in a rat animal model. 37th workshop on Inner Ear Biology September 2-5 2000, Upsala Sweden.

  • 14. Martini A, Hatzopoulos S, Petruccelli J, Pelosi G, Kibbe K, Guerrini M, Vigi V. Transient and Distortion Product Otoacoustic Emission Protocols Applied on Low-Birth NICU residents, NHS conference on Neonatal Screening, Milano October 12-14, 2000.

  • 15. Martini A, Hatzopoulos S, Pelosi G, Petruccelli J, Vigi F, Chierici M. An overview of efficient Otoacoustic Emission protocols employed in a Hospital-based neonatal screening program . Collegium ORLAS meeting, August 20-24, 2000 Washington DC.

  • 16. Hatzopoulos S., Pelosi G., Prosser S., Guerrini F., Vigi G.,, and Martini A. "Efficient otoacoustic emission protocols applied on low birth-weight NICU residents" International Congress of Audiology, 27-31 August 2000, Hague. Holland.

  • 17. Hatzopoulos, J. Petruccelli, M. Di Stefano, and A. Martini The suppressing effect of xylazine-ketamine anesthesia on transient (TEOAE) and distortion product (DPOAE) otoacoustic emissions in a rat animal model. 37th workshop on Inner Ear Biology September 2-5 2000, Upsala Sweden.

  • 18. Martini A, Hatzopoulos S, Petruccelli J, Pelosi G, Kibbe K, Guerrini M, Vigi V. Transient and Distortion Product Otoacoustic Emission Protocols Applied on Low-Birth NICU residents, NHS conference on Neonatal Screening, Milano October 12-14, 2000.

  • 19. Hatzopoulos S., Petruccelli. G, Martini A. Lewis, D.R., Russo, ICP and Almeida, K. Neonatal screening with DPOEs protocols in Italy and Brazil. American Academy of Audiology, Annual meeting, Chicago March 17-19, 2001.

  • 20. Hatzopoulos S., Petruccelli J.,Kibbe K., and Martini A. Otoacoustic Emission Responses from Low-Birth NICU residents, American Society of Audiology, Annual meeting, Scottsdale Arizona, March 15-17, 2001.

  • 21. Grzanka A, Konopka W, Hatzopoulos S, Zalewski P. TEOAE high resolution time-frequency components and their long term stability, IERASG meeting June 21-27 Vancouver Canada, 2001.

  • 22. Hatzopoulos S. Petruccelli J., and Martini A. Evaluation of anesthesia effects in a rat animal model using hig and medium stimulus intensity otoacoustic emission protocols. Inner Ear Biology meeting, Rome, September 1-4, 2001.

  • 23. S. Hatzopoulos, T. Morlet, J. Petruccelli , P. Guerrini, Rigon F, Rossi M and A. Martini Factors affecting the maturation of OAE responses of Low-Birth NICU residents, NHS meeting Como, May 31, 2002.

  • 24. Martini A, Previati M, Bertolaso L, Lanzoni I, Bindini D, Hatzopoulos S, Capitani S Singnal transduction due to ototoxic drugs in OCK3. Pharmacological protection of the Inner Ear, Rome May 3-4, 2002.


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